Pattern recognition receptors in GtoPdb v.2023.1
نویسندگان
چکیده
Pattern Recognition Receptors (PRRs, [110]) (nomenclature as agreed by NC-IUPHAR sub-committee on Receptors, [20]) participate in the innate immune response to microbial agents, stimulation of which leads activation intracellular enzymes and regulation gene transcription. PRRs express multiple leucine-rich regions bind a range microbially-derived ligands, termed PAMPs or pathogen-associated molecular patterns endogenous DAMPS damage-associated patterns. These include peptides, carbohydrates, peptidoglycans, lipoproteins, lipopolysaccharides, nucleic acids. both cell-surface proteins. may be divided into signalling-associated members, identified here, endocytic function appears recognise particular motifs for subsequent cell attachment, internalisation destruction. Some are involved inflammasome formation, modulation IL-1β cleavage secretion, others initiation type I interferon response. included Guide To PHARMACOLOGY are:Catalytic (see links below this overview)Toll-like receptors (TLRs)Nucleotide-binding oligomerization domain, repeat containing (NLRs, also known NOD (Nucleotide oligomerisation domain)-like receptors)RIG-I-like (RLRs)Caspase 4 caspase 5 Non-catalytic PRRsAbsent melanoma (AIM)-like (ALRs)C-type lectin-like (CLRs)Other pattern recognition receptorsAdvanced glycosylation end-product specific receptor (RAGE)
منابع مشابه
[Pattern recognition receptors].
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ژورنال
عنوان ژورنال: IUPHAR/BPS guide to pharmacology CITE
سال: 2023
ISSN: ['2633-1020']
DOI: https://doi.org/10.2218/gtopdb/f302/2023.1